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Genentech Oncology

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As the understanding of oncology progresses, it has become clear that the fight against cancer requires innovation from many angles. With a multifaceted approach to research and development, we are investigating a broad range of antitumor modalities, including individualized neoantigen-specific therapy, innovative bispecific antibodies, and novel antibody drug conjugates.

In the continued pursuit of truly personalized healthcare, we aim to improve specificity across all development platforms, to further identify the right approach for the right patient, and to transform the way cancer is treated in areas of unmet clinical need. 

 

Antibody Drug Conjugates

Antibody Drug Conjugates

See the science behind Genentech's continued development of antibody drug conjugates (ADCs) and the potential of delivering highly potent cytotoxins directly to malignant B cells and other tumors.1,2

Explore ADCs
Individualized NeoAntigen Specific Immunotherapy (iNeST)

Individualized Neoantigen-Specific Immunotherapy (iNeST)

Learn more about the potential of inducing antitumor immune responses through our investigational Individualized NeoAntigen Specific Immunotherapy (iNeST).3

Explore iNeST
Monoclonal Antibodies

Monoclonal Antibodies

Read more about our diverse approaches to transforming the innate ability of antibodies into potential therapeutic agents against cancer.4

Explore Monoclonal Antibodies
Small Molecules

Small Molecules

Read more about our continued research in targeting intracellular tumor mechanisms to interrupt pathway dysregulation.5,6

Explore Small Molecules
Bispecific Antibodies

Bispecific Antibodies

Discover our unique bispecific antibody design technologies and the innovative method of harnessing the immune system to fight cancer through the simultaneous binding of T cells and tumor-cell antigens.7,8

Explore Bispecific Antibodies
Register for updates to stay connected to oncology research, news, and developments from Genentech Oncology.

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      Peters C, Brown S. Antibody-drug conjugates as novel anti-cancer chemotherapeutics. Biosci Rep. 2015;35(4). doi:10.1042/BSR20150089. PMID: 26182432

    • Polson AG, Yu S-F, Elkins K, et al. Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma. Blood. 2007;110:616-623. PMID: 17374736

      Polson AG, Yu S-F, Elkins K, et al. Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma. Blood. 2007;110:616-623. PMID: 17374736

    • Sahin U, Derhovanessian E, Miller M, et al. Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer. Nature. 2017;547:222-226. PMID: 28678784

      Sahin U, Derhovanessian E, Miller M, et al. Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer. Nature. 2017;547:222-226. PMID: 28678784

    • Strome SE, Sausville EA, Mann D. A mechanistic perspective of monoclonal antibodies in cancer therapy beyond target-related effects. Oncologist. 2007;12:1084-1095. PMID: 17914078

      Strome SE, Sausville EA, Mann D. A mechanistic perspective of monoclonal antibodies in cancer therapy beyond target-related effects. Oncologist. 2007;12:1084-1095. PMID: 17914078

    • Hanahan D, Weinberg D. Hallmarks of cancer: the next generation. Cell. 2011;144:646-674. PMID: 21376230

      Hanahan D, Weinberg D. Hallmarks of cancer: the next generation. Cell. 2011;144:646-674. PMID: 21376230

    • Manning BD, Toker A. AKT/PKB signaling: navigating the network. Cell. 2017;169:381-405. PMID: 28431241

      Manning BD, Toker A. AKT/PKB signaling: navigating the network. Cell. 2017;169:381-405. PMID: 28431241

    • Bacac M, Klein C, Umana P. Oncoimmunology. 2016;5:e1203498. PMID: 27622073

      Bacac M, Klein C, Umana P. Oncoimmunology. 2016;5:e1203498. PMID: 27622073

    • Bacac M, Fauti T, Sam J, et al. Clin Cancer Res. 2016;22:3286-3297. PMID: 26861458

      Bacac M, Fauti T, Sam J, et al. Clin Cancer Res. 2016;22:3286-3297. PMID: 26861458