Researching Cancer Immunity Targets

The immune system plays a crucial role in protecting the body against cancer by recognizing and destroying cells it perceives as foreign. Cancer immunity strategies aim to restore the immune system's abilities to mobilize an antitumor immune response.1

Some strategies aim to override the mechanisms that prevent T cells from mounting an immune response. Some aim to negate the mechanisms that prevent T cells from infiltrating the tumor microenvironment. Others seek to stimulate an immune response, thereby strengthening detection and destruction of newly transformed or developing tumors and reducing the likelihood of further tumor growth and metastases.1,2

Since multiple immune inhibitory mechanisms are often present concurrently, we aim to evaluate and develop diverse combination strategies to optimize the antitumor immune response.3

Immune phenotypes

Immune phenotypes characterize the critical points at which cancer immunity fails

Immune desert2

Immune excluded5

Inflamed5

Cancer immunity cycle

Establishing the scientific foundation of cancer immunity research1

Step 1: Antigen release1

Step 2: Antigen presentation1

Step 3: Priming and activation1

Step 4: T-cell trafficking1

Step 5: T-cell infiltration1

Step 6: T-cell recognition1

Step 7: T-cell–mediated killing* of tumor cells1

*Tumor cell killing by CD8+ T cells.

References