Genentech Oncology
Carcinoembryonic antigen (CEA) is a cell-surface protein that mediates intracellular adhesion.1
CD3 (cluster of differentiation 3) is a multimeric protein composed of 4 subunits (γ, δ, ε, ζ), which are part of the T-cell receptor complex on the surface of T cells.6
Binding of a T-cell bispecific antibody to CEA on tumor cells and CD3 on T cells engages T cells and redirects their activity against tumor cells. T-cell activation—a result of the CEA-CD3 interaction—promotes the proliferation/expansion of pre-existing T cells and the recruitment of new T cells from the peripheral blood to the tumor microenvironment, which may further contribute to antitumor activity.2
Beauchemin N, Arabzadeh A. Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis. Cancer Metastasis Rev. 2013;32:643-671. PMID: 23903773
Beauchemin N, Arabzadeh A. Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis. Cancer Metastasis Rev. 2013;32:643-671. PMID: 23903773
Bacac M, Klein C, Umana P. Oncoimmunology. 2016;5:e1203498. PMID: 27622073
Bacac M, Klein C, Umana P. Oncoimmunology. 2016;5:e1203498. PMID: 27622073
Dallas MR, Liu G, Chen W-C, et al. Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis. FASEB J. 2012;26:2648-2656. PMID: 22415308
Dallas MR, Liu G, Chen W-C, et al. Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis. FASEB J. 2012;26:2648-2656. PMID: 22415308
Morse MA, Clay TM, Lyerly HK. Tumor antigens. In: Kaufman HL, Wolchok JD, eds. General Principles of Tumor Immunotherapy. Dordrecht, The Netherlands: Springer; 2007:23.
Morse MA, Clay TM, Lyerly HK. Tumor antigens. In: Kaufman HL, Wolchok JD, eds. General Principles of Tumor Immunotherapy. Dordrecht, The Netherlands: Springer; 2007:23.
Hammarström S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol. 1999;9:67-81. PMID: 10202129
Hammarström S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol. 1999;9:67-81. PMID: 10202129
Borroto A, Arellano I, Blanco R, et al. Relevance of Nck-CD3ε interaction for T cell activation in vivo. J Immunol. 2014;192:2042-2053. PMID: 24470497
Borroto A, Arellano I, Blanco R, et al. Relevance of Nck-CD3ε interaction for T cell activation in vivo. J Immunol. 2014;192:2042-2053. PMID: 24470497
Bacac M, Fauti T, Sam J, et al. Clin Cancer Res. 2016;22:3286-3297. PMID: 26861458
Bacac M, Fauti T, Sam J, et al. Clin Cancer Res. 2016;22:3286-3297. PMID: 26861458
Lehmann S, Perera R, Grimm H-P, et al. Clin Cancer Res. 2016;22:4417-4427. PMID: 27117182
Lehmann S, Perera R, Grimm H-P, et al. Clin Cancer Res. 2016;22:4417-4427. PMID: 27117182
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