Targeted strategies aim to recognize altered or overexpressed proteins and their associated pathways.1,2 How cancer cells exploit these signaling pathways is still unknown and remains a core topic in cancer research and an important area of investigation for us.
Many intricate differences exist among tumor types and across patients, and some signaling pathways exhibit the ability to influence an immune response.2 With a focus on combination regimens, we aim to advance a personalized approach, and a more comprehensive understanding of cancer and its complexities.
Through scientific discovery, we are dedicated to advancing the fight against cancer and identifying the next generation of targeted strategies.
Read more about the role of ALK in cancer.
Investigate BCL-2 and its role in apoptosis.
Learn more about CD79b and its role in B-cell malignancies.
Discover more about the HER family and its role in tumorigenesis
Read about targeting KRAS G12C, a driver mutation in cancer.
Learn about the MAPK signaling pathway and its role in cell growth and survival.
Learn about the role of NTRK Gene Fusions in oncogenesis.
Learn more about the PI3K pathways and its role in cancer.
Learn about the role of ROS1 in NSCLC oncogenesis.
Read more about the role of VEGF in tumor angiogenesis.
Chen K, Chen X. Positron emission tomography imaging of cancer biology: current status and future prospects. Semin Oncol. 2011;38:70-86. PMID: 21362517
Luo J, Solimini NL, Elledge SE. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell. 2009;136:823-837. PMID: 19269363
Hanahan D, Weinberg D. Hallmarks of cancer: the next generation. Cell. 2011;144:646-674. PMID: 21376230
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