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Researching Tumor Targets and Pathways in Cancer

Targeted strategies aim to recognize altered or overexpressed proteins and their associated pathways.1,2 How cancer cells exploit these signaling pathways is still unknown and remains a core topic in cancer research and an important area of investigation for us.

Many intricate differences exist among tumor types and across patients, and some signaling pathways exhibit the ability to influence an immune response.2 With a focus on combination regimens, we aim to advance a personalized approach, and a more comprehensive understanding of cancer and its complexities.

Through scientific discovery, we are dedicated to advancing the fight against cancer and identifying the next generation of targeted strategies.

 

ALK

ALK

Read more about the role of ALK in cancer.

BCL-2

BCL-2

Investigate BCL-2 and its role in apoptosis.

CD79b

CD79b

Learn more about CD79b and its role in B-cell malignancies.

HER Pathways

HER Pathways

Discover more about the HER family and its role in tumorigenesis

KRAS G12C

KRAS G12C

Read about targeting KRAS G12C, a driver mutation in cancer.

MAPK

MAPK

Learn about the MAPK signaling pathway and its role in cell growth and survival.

NTRK

NTRK Gene Fusions

Learn about the role of NTRK Gene Fusions in oncogenesis.

PI3K

PI3K

Learn more about the PI3K pathways and its role in cancer.

ROS1

ROS1

Learn about the role of ROS1 in NSCLC oncogenesis.

VEGF

VEGF

Read more about the role of VEGF in tumor angiogenesis.

    • Chen K, Chen X. Positron emission tomography imaging of cancer biology: current status and future prospects. Semin Oncol. 2011;38:70-86. PMID: 21362517

      Chen K, Chen X. Positron emission tomography imaging of cancer biology: current status and future prospects. Semin Oncol. 2011;38:70-86. PMID: 21362517

    • Luo J, Solimini NL, Elledge SE. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell. 2009;136:823-837. PMID: 19269363

      Luo J, Solimini NL, Elledge SE. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell. 2009;136:823-837. PMID: 19269363

    • Hanahan D, Weinberg D. Hallmarks of cancer: the next generation. Cell. 2011;144:646-674. PMID: 21376230

      Hanahan D, Weinberg D. Hallmarks of cancer: the next generation. Cell. 2011;144:646-674. PMID: 21376230