NTRK Gene Fusions: A Driver of Oncogenesis1

TRK pathway signaling may drive tumor survival and growth2

  • In normal healthy tissue, the TRK pathway plays a role in the development of the central and peripheral nervous systems and pain sensation3
  • In a wide range of cancer types NTRK gene fusions can occur, leading to genetically altered TRK receptor proteins that may drive signaling pathways involved in cell proliferation, survival, invasion, and angiogenesis2

What are NTRK gene fusions?


AKT=v-akt murine thymoma viral oncogene homologue; DAG=diacyl-glycerol; ERK=extracellular signal-regulated kinase; MEK=mitogen-activated protein kinase; mTOR=mammalian target of rapamycin; NTRK=neurotrophic tyrosine receptor kinase;
PI3K=phosphatidylinositol-4,5-bisphosphate 3-kinase; PKC=protein kinase C; PLCy=phospholipase C gamma; RAF=rapidly accelerated fibrosarcoma kinase; Ras=rat sarcoma kinase; TRK=tropomyosin receptor kinase.


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