Acute myeloid leukemia
Brain lower grade glioma
Congenital mesoblastic nephroma
Gastrointestinal stromal tumors
Head and neck squamous cell carcinoma
Large cell neuroendocrine tumor
Mammary analogue secretory carcinoma
Non-small cell lung cancer
Papillary thyroid cancer
Ph-like acute lymphoblastic leukemia
Secretory breast carcinoma
Skin cutaneous melanoma
Cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence complementarity.
A protein created by joining different genes that are transcribed and translated as a single unit.
Uses antibodies to detect the target protein on tissue sections.
Tropomyosin receptor kinase. Members of the TRK protein family of receptors, TRKA, TRKB, and TRKC, are encoded by the 3 NTRK genes, NTRK1, NTRK2, and NTRK3, respectively.
AKT=v-akt murine thymoma viral oncogene homologue; DAG=diacyl-glycerol; ERK=extracellular signal-regulated kinase; MEK=mitogen-activated protein kinase; mTOR=mammalian target of rapamycin; NTRK=neurotrophic tyrosine receptor kinase;
PI3K=phosphatidylinositol-4,5-bisphosphate 3-kinase; PKC=protein kinase C; PLCy=phospholipase C gamma; RAF=rapidly accelerated fibrosarcoma kinase; Ras=rat sarcoma kinase; TRK=tropomyosin receptor kinase.
Chong CR, Bahcall M, Capelletti M, et al. Identification of existing drugs that effectively target NTRK1 and ROS1 rearrangements in lung cancer. Clin Cancer Res. 2017;23(1):204-213. PMID: 27370605
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