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Watch how NTRK gene fusions drive oncogenesis.
Cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence complementarity.
A protein created by joining different genes that are transcribed and translated as a single unit.
Uses antibodies to detect the target protein on tissue sections.
Tropomyosin receptor kinase. Members of the TRK protein family of receptors, TRKA, TRKB, and TRKC, are encoded by the 3 NTRK genes, NTRK1, NTRK2, and NTRK3, respectively.
AKT=v-akt murine thymoma viral oncogene homologue; DAG=diacyl-glycerol; ERK=extracellular signal-regulated kinase; MEK=mitogen-activated protein kinase; mTOR=mammalian target of rapamycin; NTRK=neurotrophic tyrosine receptor kinase;
PI3K=phosphatidylinositol-4,5-bisphosphate 3-kinase; PKC=protein kinase C; PLCy=phospholipase C gamma; RAF=rapidly accelerated fibrosarcoma kinase; Ras=rat sarcoma kinase; TRK=tropomyosin receptor kinase.
Vaishnavi A, Le AT, Doebele RC. Cancer Discov. 2015;5(1):25-34. PMID: 25527197
Vaishnavi A, Le AT, Doebele RC. Cancer Discov. 2015;5(1):25-34. PMID: 25527197
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Amatu A, Sartore-Bianchi A, Siena S. ESMO Open. 2016;1(2):e000023. PMID: 27843590
Chong CR, Bahcall M, Capelletti M, et al. Identification of existing drugs that effectively target NTRK1 and ROS1 rearrangements in lung cancer. Clin Cancer Res. 2017;23(1):204-213. PMID: 27370605
Chong CR, Bahcall M, Capelletti M, et al. Identification of existing drugs that effectively target NTRK1 and ROS1 rearrangements in lung cancer. Clin Cancer Res. 2017;23(1):204-213. PMID: 27370605
Shaw AT, Hsu PP, Awad MM, Engelman JA. Nat Rev Cancer. 2013;13(11):772-787. PMID: 24132104
Shaw AT, Hsu PP, Awad MM, Engelman JA. Nat Rev Cancer. 2013;13(11):772-787. PMID: 24132104
Kheder ES, Hong DS. Clin Cancer Res. 2018:1156. [Epub ahead of print.] PMID: 29986850
Kheder ES, Hong DS. Clin Cancer Res. 2018:1156. [Epub ahead of print.] PMID: 29986850
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