What is ROS1?

The ROS1 signaling pathway has been associated with cancer development1,2

  • Genetic rearrangements of ROS1 have been identified in various cancer types and widely studied in non-small cell lung cancer (NSCLC)2
  • While ROS1 is expressed in normal healthy cells, it is not normally expressed in the lung2
    • The role of ROS1 in normal development is not fully understood2
  • ROS1 gene rearrangements are the primary drivers of disease in ROS1+ NSCLC2

The ROS1 signaling pathway1-4

AKT=v-akt murine thymoma viral oncogene homologue; ERK=extracellular signal-regulated kinase; JAK=Janus kinase; MEK=mitogen-activated protein kinase; mTOR=mammalian target of rapamycin; NSCLC=non-small cell lung cancer; PI3K=phosphatidylinositol-4,5-bisphosphate 3-kinase; RAF=rapidly accelerated fibrosarcoma kinase; Ras=rat sarcoma kinase; ROS1=ROS proto-oncogene 1; STAT=signal transducer and activator of transcription.

ROS1: A driver of NSCLC oncogenesis1,2

CNS metastasis in ROS1+ NSCLC



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