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Tumor Types

Investigational Therapies

These compounds and their uses are investigational and have not been approved by the US Food and Drug Administration. Efficacy and safety have not been established. The information presented should not be construed as a recommendation for use. The relevance of findings in preclinical studies to humans is currently being evaluated.

Showing 87 out of 87 results

Phase III

Breast

  • Giredestrant
    (SERD)

    (GDC-9545, RG6171)
    Breast
  • Inavolisib
    (PI3K alpha inhibitor)

    (GDC-0077, RG6114)
    Breast
  • Ipatasertib
    (AKT inhibitor)

    (RG7440, GDC-008)a
    Breast

Gastrointestinal

  • Atezolizumab
    (anti-PD-L1 MAb)

    (RG7446)b
    Gastrointestinal
  • Tiragolumab
    (anti-TIGIT)

    (MTIG7192A, RG6058)
    Gastrointestinal
    Lung

Hematology

  • Glofitamab
    (anti-CD20 x CD3)

    (RG6026)
    Hematology
  • Mosunetuzumab
    (anti-CD20 x CD3)

    (RG7828)
    Hematology
  • Venetoclax
    (BCL-2 inhibitor)

    (RG7601)c
    Hematology

Lung

Phase II

Gastrointestinal

  • Atezolizumab
    (anti-PD-L1 MAb)

    (RG7446)b
    Gastrointestinal
    Hematology
    Solid Tumor
  • PD-1 x LAG3

    (RG6139)
    Gastrointestinal
    Melanoma

Hematology

  • Atezolizumab
    (anti-PD-L1 MAb)

    (RG7446)b
    Gastrointestinal
    Hematology
    Solid Tumor
  • Cevostamab
    (anti-FcRH5 x CD3)

    (RG6160)
    Hematology
  • Glofitamab
    (anti-CD20 x CD3)

    (RG6026)
    Hematology
  • Mosunetuzumab
    (anti-CD20 x CD3)

    (RG7828)
    Hematology
  • Venetoclax
    (BCL-2 inhibitor)

    (ABT-199, RG7601)c
    Hematology

Lung

Melanoma

Solid Tumor

  • Atezolizumab
    (anti-PD-L1 MAb)

    (RG7446)b
    Gastrointestinal
    Hematology
    Solid Tumor
  • Camonsertib (ATR inhibitor)

    (RG6526)d
    Solid Tumor
  • MAGE-A4 ImmTAC

    (RG6290)e
    Solid Tumor

Phase I

Brain

Breast

  • Atezolizumab
    (anti-PD-L1 MAb)

    (RG7446)b
    Breast
    Gastrointestinal
    Genitourinary
    Gynecologic
    Head Neck
    Hematology
    Solid Tumor
  • Inavolisib
    (PI3K alpha inhibitor)

    (GDC-0077, RG6114)
    Breast
    Solid Tumor
  • New molecular entity (NME)

    (RG6411)
    Breast
    Gastrointestinal
    Genitourinary
    Gynecologic
    Head Neck
    Lung
    Melanoma
    Solid Tumor
  • Runimotamab
    (HER2 x CD3)

    (RG6194)
    Breast
    Gastrointestinal
    Solid Tumor

Gastrointestinal

  • Atezolizumab
    (anti-PD-L1 MAb)

    (RG7446)b
    Breast
    Gastrointestinal
    Genitourinary
    Gynecologic
    Head Neck
    Hematology
    Solid Tumor
  • Cibisatamab
    (CEA x CD3)

    (RG7802)
    Gastrointestinal
  • FAP x 4-1BBL

    (RG7827)
    Gastrointestinal
  • GDC-6036
    (KRAS G12C inhibitor)

    (RG6330)
    Gastrointestinal
    Lung
    Solid Tumor
  • New molecular entity (NME)

    (RG6286)
    Gastrointestinal
  • New molecular entity (NME)

    (RG6411)
    Breast
    Gastrointestinal
    Genitourinary
    Gynecologic
    Head Neck
    Lung
    Melanoma
    Solid Tumor
  • PD-1 x LAG3

    (RG6139)
    Gastrointestinal
    Lung
    Melanoma
    Solid Tumor
  • Runimotamab
    (HER2 x CD3)

    (RG6194)
    Breast
    Gastrointestinal
    Solid Tumor

Genitourinary

  • Atezolizumab
    (anti-PD-L1 MAb)

    (RG7446)b
    Breast
    Gastrointestinal
    Genitourinary
    Gynecologic
    Head Neck
    Hematology
    Solid Tumor
  • New molecular entity (NME)

    (RG6411)
    Breast
    Gastrointestinal
    Genitourinary
    Gynecologic
    Head Neck
    Lung
    Melanoma
    Solid Tumor

Gynecologic

  • Atezolizumab
    (anti-PD-L1 MAb)

    (RG7446)b
    Breast
    Gastrointestinal
    Genitourinary
    Gynecologic
    Head Neck
    Hematology
    Solid Tumor
  • New molecular entity (NME)

    (RG6411)
    Breast
    Gastrointestinal
    Genitourinary
    Gynecologic
    Head Neck
    Lung
    Melanoma
    Solid Tumor
  • SPYK04

    (CHU)g
    Gynecologic
    Lung
    Solid Tumor

Head Neck

  • Atezolizumab
    (anti-PD-L1 MAb)

    (RG7446)b
    Breast
    Gastrointestinal
    Genitourinary
    Gynecologic
    Head Neck
    Hematology
    Solid Tumor
  • New molecular entity (NME)

    (RG6411)
    Breast
    Gastrointestinal
    Genitourinary
    Gynecologic
    Head Neck
    Lung
    Melanoma
    Solid Tumor
  • SHP2i
    (SHP2 inhibitor)

    (RG6433)
    Head Neck
    Lung
    Melanoma
    Solid Tumor

Hematology

  • Atezolizumab
    (anti-PD-L1 MAb)

    (RG7446)b
    Breast
    Gastrointestinal
    Genitourinary
    Gynecologic
    Head Neck
    Hematology
    Solid Tumor
  • CD19 x 4-1BBL

    (RG6076)
    Hematology
  • CD19 x CD28

    (RG6333)
    Hematology
  • Cevostamab
    (anti-FcRH5 x CD3)

    (RG6160)
    Hematology
  • Forimtamig
    (GPRC5D x CD3)

    (RG6234)
    Hematology
  • Glofitamab
    (anti-CD20 x CD3)

    (RG6026)
    Hematology
  • HLA-A2-WT1 x CD3

    (RG6007)
    Hematology
  • IL15/IL15Ra-Fc

    (RG6323)h
    Hematology
    Solid Tumor
  • Mosunetuzumab
    (anti-CD20 x CD3)

    (RG7828)
    Hematology
  • P-BCMA-ALLO1

    (RG6538)i
    Hematology

Lung

  • GDC-6036
    (KRAS G12C inhibitor)

    (RG6330)
    Gastrointestinal
    Lung
    Solid Tumor
  • New molecular entity (NME)

    (RG6524)
    Lung
    Solid Tumor
  • New molecular entity (NME)

    (RG6411)
    Breast
    Gastrointestinal
    Genitourinary
    Gynecologic
    Head Neck
    Lung
    Melanoma
    Solid Tumor
  • PD-1 x LAG3

    (RG6139)
    Gastrointestinal
    Lung
    Melanoma
    Solid Tumor
  • SHP2i
    (SHP2 inhibitor)

    (RG6433)
    Head Neck
    Lung
    Melanoma
    Solid Tumor
  • SPYK04

    (CHU)g
    Gynecologic
    Lung
    Solid Tumor

Melanoma

  • BRAF inhibitor (3)

    (RG6344)
    Melanoma
    Solid Tumor
  • New molecular entity (NME)

    (RG6411)
    Breast
    Gastrointestinal
    Genitourinary
    Gynecologic
    Head Neck
    Lung
    Melanoma
    Solid Tumor
  • PD-1 x LAG3

    (RG6139)
    Gastrointestinal
    Lung
    Melanoma
    Solid Tumor
  • SHP2i
    (SHP2 inhibitor)

    (RG6433)
    Head Neck
    Lung
    Melanoma
    Solid Tumor

Solid Tumor

  • Atezolizumab
    (anti-PD-L1 MAb)

    (RG7446)b
    Breast
    Gastrointestinal
    Genitourinary
    Gynecologic
    Head Neck
    Hematology
    Solid Tumor
  • BRAF inhibitor (3)

    (RG6344)
    Melanoma
    Solid Tumor
  • Belvarafenib
    (pan-RAF inhibitor)

    (RG6185)
    Solid Tumor
  • CD25 MAb

    (RG6292)
    Solid Tumor
  • Camonsertib (ATR inhibitor)

    (RG6526)d
    Solid Tumor
  • Cobimetinib (MEK inhibitor)

    N/A
    Solid Tumor
  • FAP-CD40

    (RG6189)
    Solid Tumor
  • GDC-6036
    (KRAS G12C inhibitor)

    (RG6330)
    Gastrointestinal
    Lung
    Solid Tumor
  • IL15/IL15Ra-Fc

    (RG6323)h
    Hematology
    Solid Tumor
  • Inavolisib
    (PI3K alpha inhibitor)

    (GDC-0077, RG6114)
    Breast
    Solid Tumor
  • LUNA18

    (CHU)g
    Solid Tumor
  • MAGE-A4 ImmTAC

    (RG6290)e
    Solid Tumor
  • New molecular entity (NME)

    (RG6524)
    Lung
    Solid Tumor
  • New molecular entity (NME)

    (RG6411)
    Breast
    Gastrointestinal
    Genitourinary
    Gynecologic
    Head Neck
    Lung
    Melanoma
    Solid Tumor
  • PD-1 x IL2v

    (RG6279)
    Solid Tumor
  • PD-1 x LAG3

    (RG6139)
    Gastrointestinal
    Lung
    Melanoma
    Solid Tumor
  • Runimotamab
    (HER2 x CD3)

    (RG6194)
    Breast
    Gastrointestinal
    Solid Tumor
  • SHP2i
    (SHP2 inhibitor)

    (RG6433)
    Head Neck
    Lung
    Melanoma
    Solid Tumor
  • SPYK04

    (CHU)g
    Gynecologic
    Lung
    Solid Tumor

No results were found


aDeveloped in collaboration with Array Biopharma.bDeveloped in collaboration with Exelixis. cJoint project with AbbVie. dManaged by Repare Therapeutics. eDeveloped in collaboration with Immunocore. fDeveloped in collaboration with Relay Therapeutics. gDeveloped in collaboration with Chugai. hDeveloped in collaboration with Xencor. iManaged by Poseida Therapeutics.
Current as of February 2, 2023. The trial information is taken from ClinicalTrials.gov.

    • Roche. 2022 Q4 results. February 2, 2023. Accessed February 15, 2023. https://assets.cwp.roche.com/f/126832/x/5738a7538b/irp230202.pdf

      Roche. 2022 Q4 results. February 2, 2023. Accessed February 15, 2023. https://assets.cwp.roche.com/f/126832/x/5738a7538b/irp230202.pdf